Nor Nadia, Alies (2012) Thermal characteristics of paracetamol granules prepared using method of spray granulation employing kappa-carrageenan as binder / Nor Nadia Alies. Masters thesis, University of Malaya.
Abstract
Granules offer advantages as an intermediate for compression of tablets. Granules can be formed by one of the technique using the fluid bed spray granulator or the spray granulation method. This technique reduces costs by combining the processes in one instrument (mixing, granulating and drying). Differential scanning calorimeter (DSC) was used as a screening technique for assessing the compatibility of paracetamol with kappa-carrageenan which is used as binder. The influence of processing effects by simple drug-excipient blending at different w: w ratio (1:1, 2;1 and 4:1) and granulation was evaluated. The results of the DSC screening show that paracetamol is compatible with kappa-carrageenan. Some changes in peak shape and height-to-width ratio or slight reduction of temperature of melting were sometimes observed for kappa-carageenan but the active drug, Paracetamol thermal characteristic are not significantly change (P>0.05). Kappa-carrageenan shows significantly decrease or a noticeable downward shift of melting peak temperatures of about 41oC (P <0.05). We can conclude that the interaction of Paracetamol with kappa- carrageenan is not significant as there is no significant changes in the thermal characteristics of paracetamol. The SEM scanning shows the morphology of the granules form.
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