Siti Mariam , Abdul Wahab (2016) Natural cholinesterase inhibitors from Myristica cinnamomea king / Siti Mariam Abdul Wahab. Masters thesis, University of Malaya.
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Abstract
A new acylphenol, malabaricone E (72) together with the known malabaricones A-C (1- 3), maingayones A and B (4 and 5) and maingayic acid B (69) were isolated from the ethyl acetate extract of the fruits of Myristica cinnamomea King. Their structures were determined by 1D and 2D NMR techniques and LCMS-IT-TOF analysis. Compounds 2 (1.84 ± 0.19 and 1.76 ± 0.21 μM, respectively) and 3 (1.94 ± 0.27 and 2.80 ± 0.49 μM, respectively) were identified as dual inhibitors, with almost equal acetylcholinesterase enzyme (AChE) and butyrylcholinesterase enzyme (BChE) inhibiting potentials. The Lineweaver-Burk plots of compounds 2 and 3 indicated that they were mixed-mode inhibitors. Based on the molecular docking studies, compounds 2 and 3 interacted with the peripheral anionic site (PAS), the catalytic triad and the oxyanion hole of the AChE. As for the BChE, while compound 2 interacted with the PAS, the catalytic triad and the oxyanion hole, compound 3 only interacted with the catalytic triad and the oxyanion hole.
| Item Type: | Thesis (Masters) |
|---|---|
| Additional Information: | Dissertation (M.A.) – Faculty of Science, University of Malaya, 2016. |
| Uncontrolled Keywords: | Myristica cinnamomea king; Peripheral anionic site (PAS); Oxyanion hole; Catalytic triad; Mixed-mode inhibitors |
| Subjects: | Q Science > Q Science (General) |
| Divisions: | Faculty of Science |
| Depositing User: | Mr Mohd Safri Tahir |
| Date Deposited: | 05 Aug 2019 06:55 |
| Last Modified: | 05 Aug 2019 06:55 |
| URI: | http://studentsrepo.um.edu.my/id/eprint/9665 |
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