Lipid nanoparticles in thermoresponsive gel for topical application / Lim Qian Ying

Lim , Qian Ying (2017) Lipid nanoparticles in thermoresponsive gel for topical application / Lim Qian Ying. Masters thesis, University of Malaya.

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Abstract

Medicated topical gel having thermoresponsive feature is advantageous with respect to spreadability and drug delivery. However, gels are restricted by insolubility due to the hydrophobic drug compounds used and chemical degradation of active compounds in an aqueous system. Therefore, lipid nanoparticles are incorporated as a carrier for the active ingredients. In present work, alpha-tocopherol and hydroquinone were loaded in lecithin-fatty acid nanoparticles which was then incorporated into a thermoresponsive gel, consisting of carboxymethyl cellulose (CMC) and iota-carrageenan (ι-C). Temperature and Ca2+ ions effect on the rheological behavior of the prepared gel mixture was investigated. The nanostructured lipid carrier (NLC) was evaluated for its mean particle size, zeta potential, morphology, encapsulation efficiency and in vitro release. Physicochemical characterization showed that both alpha-tocopherol and hydroquinone loaded NLCs being stored at 4 ˚C were stable for 30 days, while the encapsulation efficiency was different more than 30% due to the distinct hydrophobicity. In vitro release studies showed that NLC had the capability to slow release both the hydrophobic and hydrophilic active ingredients. Meanwhile, a gel system was formulated to transform from gel-like to liquid-like consistency in the vicinity of body temperature. NLC gave advantages to the pure gel system as the NLC-gel showed slightly higher elasticity, indicating contribution of NLC to rigidity of the gel system. Nevertheless, the effect of NLC on gelling point was negligible. These results suggest that gel mixture of CMC and ι-C is likely to be developed as a thermoresponsive gel while NLC is a potential active ingredient carrier system in topical application.

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